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BMCBI
2005
90views more  BMCBI 2005»
13 years 9 months ago
An algorithm for the determination and quantification of components of nucleic acid mixtures based on single sequencing reaction
Background: Determination and quantification of nucleic acid components in a mixture is usually accomplished by microarray approaches, where the mixtures are hybridized against sp...
Alexander E. Pozhitkov, Kathryn Stemshorn, Diethar...
BMCBI
2005
131views more  BMCBI 2005»
13 years 9 months ago
Critical evaluation of the JDO API for the persistence and portability requirements of complex biological databases
Background: Complex biological database systems have become key computational tools used daily by scientists and researchers. Many of these systems must be capable of executing on...
Marko Srdanovic, Ulf Schenk, Michael Schwieger, Fa...
BMCBI
2005
140views more  BMCBI 2005»
13 years 9 months ago
Dissecting systems-wide data using mixture models: application to identify affected cellular processes
Background: Functional analysis of data from genome-scale experiments, such as microarrays, requires an extensive selection of differentially expressed genes. Under many condition...
J. Peter Svensson, Renée X. de Menezes, Ing...
BMCBI
2005
152views more  BMCBI 2005»
13 years 9 months ago
Improved profile HMM performance by assessment of critical algorithmic features in SAM and HMMER
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Markus Wistrand, Erik L. L. Sonnhammer
BMCBI
2005
250views more  BMCBI 2005»
13 years 9 months ago
FiatFlux - a software for metabolic flux analysis from 13C-glucose experiments
Background: Quantitative knowledge of intracellular fluxes is important for a comprehensive characterization of metabolic networks and their functional operation. In contrast to d...
Nicola Zamboni, Eliane Fischer, Uwe Sauer