Motivation: Existing methods for protein sequence analysis are generally firstorder and inherently assume that each position is independent. We develop a general framework for int...
Martin Madera, Ryan Calmus, Grant Thiltgen, Kevin ...
Phylogenetic trees are widely used to display estimates of how groups of species evolved. Each phylogenetic tree can be seen as a collection of clusters, subgroups of the species ...
Leo van Iersel, Steven Kelk, Regula Rupp, Daniel H...
—The most pervasive compute operation carried out in almost all bioinformatics applications is pairwise sequence homology detection (or sequence alignment). Due to exponentially ...
This manuscript presents the most rigorous benchmarking of gene annotation algorithms for metagenomic datasets to date. We compare three different programs: GeneMark, MetaGeneAnnot...
Abstract. The orientation of physical networks is a prime task in deciphering the signaling-regulatory circuitry of the cell. One manifestation of this computational task is as a m...