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BMCBI
2008
102views more  BMCBI 2008»
13 years 9 months ago
Stability of the core domain of p53: insights from computer simulations
: The tumour suppressor protein p53 protein has a core domain that binds DNA and is the site for most oncogenic mutations. This domain is quite unstable compared to its homologs p...
Arumugam Madhumalar, Derek John Smith, Chandra Ver...
BMCBI
2008
86views more  BMCBI 2008»
13 years 9 months ago
Is plant mitochondrial RNA editing a source of phylogenetic incongruence? An answer from in silico and in vivo data sets
Background: In plant mitochondria, the post-transcriptional RNA editing process converts C to U at a number of specific sites of the mRNA sequence and usually restores phylogeneti...
Ernesto Picardi, Carla Quagliariello
BMCBI
2008
151views more  BMCBI 2008»
13 years 9 months ago
An integrated database-pipeline system for studying single nucleotide polymorphisms and diseases
Background: Studies on the relationship between disease and genetic variations such as single nucleotide polymorphisms (SNPs) are important. Genetic variations can cause disease b...
Jin Ok Yang, Sohyun Hwang, Jeongsu Oh, Jong Bhak, ...
BMCBI
2008
125views more  BMCBI 2008»
13 years 9 months ago
Tandem duplication, circular permutation, molecular adaptation: how Solanaceae resist pests via inhibitors
Background: The Potato type II (Pot II) family of proteinase inhibitors plays critical roles in the defense system of plants from Solanaceae family against pests. To better unders...
Lesheng Kong, Shoba Ranganathan
BMCBI
2008
109views more  BMCBI 2008»
13 years 9 months ago
ConStruct: Improved construction of RNA consensus structures
Background: Aligning homologous non-coding RNAs (ncRNAs) correctly in terms of sequence and structure is an unresolved problem, due to both mathematical complexity and imperfect s...
Andreas Wilm, Kornelia Linnenbrink, Gerhard Steger