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ISMB
1998
13 years 10 months ago
A Statistical Theory of Sequence Alignment with Gaps
Astatistical theory of local alignmentalgorithms with gaps is presented. Both the linear and logarithmic phases, as well as the phase transition separating the two phases, are des...
Dirk Drasdo, Terence Hwa, Michael Lässig
ISMB
1998
13 years 10 months ago
The LabFlow System for Workflow Management in Large Scale Biology Research Laboratories
LabFlowis a workflowmanagementsystem designed for large scale biologyresearch laboratories. It providesa workflowmodelin whichobjects flowfromtask to task under programmaticcontro...
Nathan Goodman, Steve Rozen, Lincoln Stein
ISMB
1998
13 years 10 months ago
Identification of Divergent Functions in Homologous Proteins by Induction over Conserved Modules
Homologousproteins do not necessarily exhibit identical biochemicalfunction. Despitethis fact, local or global sequence similarity is widely used as an indication of functional id...
Imran Shah, Lawrence Hunter
ISMB
1998
13 years 10 months ago
Phylogenetic Inference in Protein Superfamilies: Analysis of SH2 Domains
This workfocuses on the inference of evolutionary relationships in protein superfamilies, and the uses of these relationships to identify keypositions in the structure, to infer a...
Kimmen Sjölander
ISMB
1998
13 years 10 months ago
BioSim: A New Qualitative Simulation Environment for Molecular Biology
Traditionally, biochemical systems are modelled usingkinetics anddifferential equationsin a quantitative simulator. However,for manybiological processes detailed quantitative info...
Karsten R. Heidtke, Steffen Schulze-Kremer