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121
Voted
BMCBI
2005
15 years 4 months ago
2005
Background: Cellular processes require the interaction of many proteins across several cellular compartments. Determining the collective network of such interactions is an importa...
139
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BMCBI
2005
15 years 4 months ago
2005
Background: Structure-dependent substitution matrices increase the accuracy of sequence alignments when the 3D structure of one sequence is known, and are successful e.g. in fold ...
141
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BMCBI
2005
15 years 4 months ago
2005
Background: Development of robust and efficient methods for analyzing and interpreting high dimension gene expression profiles continues to be a focus in computational biology. Th...
157
Voted
BMCBI
2005
15 years 4 months ago
2005
Background: With microarray technology the expression of thousands of genes can be measured simultaneously. It is well known that the expression levels of genes of interacting pro...
154
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BMCBI
2005
15 years 4 months ago
2005
Background: Normal mode analysis (NMA) has become the method of choice to investigate the slowest motions in macromolecular systems. NMA is especially useful for large biomolecula...