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ALMOB
2006
155views more  ALMOB 2006»
13 years 7 months ago
Refining motifs by improving information content scores using neighborhood profile search
The main goal of the motif finding problem is to detect novel, over-represented unknown signals in a set of sequences (e.g. transcription factor binding sites in a genome). The mo...
Chandan K. Reddy, Yao-Chung Weng, Hsiao-Dong Chian...
BIOINFORMATICS
2006
134views more  BIOINFORMATICS 2006»
13 years 7 months ago
HaptenDB: a comprehensive database of haptens, carrier proteins and anti-hapten antibodies
The key requirement for successful immunochemical assay is the availability of antibodies with high specificity and desired affinity. Small molecules, when used as haptens, are no...
Mahender Kumar Singh, Shilpy Srivastava, G. P. S. ...
BMCBI
2006
170views more  BMCBI 2006»
13 years 7 months ago
Biclustering of gene expression data by non-smooth non-negative matrix factorization
Background: The extended use of microarray technologies has enabled the generation and accumulation of gene expression datasets that contain expression levels of thousands of gene...
Pedro Carmona-Saez, Roberto D. Pascual-Marqui, Fra...
GPEM
2008
128views more  GPEM 2008»
13 years 7 months ago
Coevolutionary bid-based genetic programming for problem decomposition in classification
In this work a cooperative, bid-based, model for problem decomposition is proposed with application to discrete action domains such as classification. This represents a significan...
Peter Lichodzijewski, Malcolm I. Heywood
BMCBI
2006
120views more  BMCBI 2006»
13 years 7 months ago
Optimizing amino acid substitution matrices with a local alignment kernel
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
Hiroto Saigo, Jean-Philippe Vert, Tatsuya Akutsu