A new computational method to study within-host viral evolution is explored to better understand the evolution and pathogenesis of viruses. Traditional phylogenetic tree methods a...
Alternative transcription, in which a single gene may give rise to multiple variant mRNA forms, is widely recognized as an important source of protein diversity in complex, eukary...
Proteases play a fundamental role in the control of intra- and extracellular processes by binding and cleaving specific amino acid sequences. Identifying these targets is extremel...
Shannon information in the genomes of all completely sequenced prokaryotes and eukaryotes are measured in word lengths of two to ten letters. It is found that in a scale-dependent...
The discovery of novel non-coding RNAs has been among the most exciting recent developments in Biology. Yet, many more remain undiscovered. It has been hypothesized that there is ...
Phylogenetic reconstruction from gene-order data has attracted attention from both biologists and computer scientists over the last few years. So far, our software suite GRAPPA is...
Jijun Tang, Bernard M. E. Moret, Liying Cui, Claud...
Clustering has been one of the most popular methods to discover useful biological insights from DNA microarray. An interesting paradigm is simultaneous clustering of both genes an...
Current motif discovery methods can only detect individual motifs in groups of protein sequences--they do not discover potentially-interacting motif pairs underlying the interacti...
In microarray gene expression data, clusters may hide in subspaces. Traditional clustering algorithms that make use of similarity measurements in the full input space may fail to ...
Kevin Y. Yip, David W. Cheung, Michael K. Ng, Kei-...