TCBB
2011
13 years 2 months ago
2011
— Probe defects are a major source of noise in gene expression studies. While existing approaches detect noisy probes based on external information such as genomic alignments, we...
TCBB
2011
13 years 2 months ago
2011
—Constructing accurate computational models that explain how ions permeate through a biological ion channel is an important problem in biophysics and drug design. Brownian dynami...
TCBB
2011
13 years 2 months ago
2011
—Protein identification is a key and essential step in mass spectrometry (MS) based proteome research. To date, there are many protein identification strategies that employ eithe...
TCBB
2011
13 years 2 months ago
2011
—In this paper, we propose a communication model of evolution and investigate its information-theoretic bounds. The process of evolution is modeled as the retransmission of infor...
TCBB
2011
13 years 2 months ago
2011
Stochastic models such as hidden Markov models or stochastic context free grammars can fail to return the correct, maximum likelihood solution in the case of semantic ambiguity. T...
TCBB
2011
13 years 2 months ago
2011
Recent experimental advances facilitate the collection of time series data that indicate which genes in a cell are expressed. This paper proposes an efficient method to generate th...
TCBB
2011
13 years 2 months ago
2011
A TOPS diagram is a simplified description of the topology of a protein using a graph where nodes are α-helices and β-strands, and edges correspond to chirality relations and p...
TCBB
2011
13 years 2 months ago
2011
: Extraction of meaningful information from large experimental datasets is a key element of bioinformatics research. One of the challenges is to identify genomic markers in Hepatit...
TCBB
2011
13 years 2 months ago
2011
—We study the problem of merging genetic maps, when the individual genetic maps are given as directed acyclic graphs. The computational problem is to build a consensus map, which...
TCAD
2011
13 years 2 months ago
2011
—Pre-bond testing of 3-D stacked integrated circuits (ICs) involves testing each individual die before bonding. The overall yield of 3-D ICs improves with pre-bond testability be...