BMCBI
2010
13 years 9 months ago
2010
Background: There is an increasing number of proteins with known structure but unknown function. Determining their function would have a significant impact on understanding diseas...
BMCBI
2010
13 years 9 months ago
2010
Background: Generally speaking, different classifiers tend to work well for certain types of data and conversely, it is usually not known a priori which algorithm will be optimal ...
BMCBI
2008
2008
Modifying the DPClus algorithm for identifying protein complexes based on new topological structures
13 years 9 months ago
Background: Identification of protein complexes is crucial for understanding principles of cellular organization and functions. As the size of protein-protein interaction set incr...
BMCBI
2008
13 years 9 months ago
2008
Background: The DNA microarray technology allows the measurement of expression levels of thousands of genes under tens/hundreds of different conditions. In microarray data, genes ...
BMCBI
2008
13 years 9 months ago
2008
Background: Automated protein function prediction methods are needed to keep pace with high-throughput sequencing. With the existence of many programs and databases for inferring ...
BMCBI
2010
13 years 9 months ago
2010
Background: All infectious disease oriented clinical diagnostic assays in use today focus on detecting the presence of a single, well defined target agent or a set of agents. In r...
BMCBI
2007
13 years 9 months ago
2007
Background: Accurate identification of novel, functional noncoding (nc) RNA features in genome sequence has proven more difficult than for exons. Current algorithms identify and s...
BMCBI
2008
13 years 9 months ago
2008
Background: Aligning RNA sequences with low sequence identity has been a challenging problem since such a computation essentially needs an algorithm with high complexities for tak...
BMCBI
2010
13 years 9 months ago
2010
Background: Traditional algorithms for hidden Markov model decoding seek to maximize either the probability of a state path or the number of positions of a sequence assigned to th...
BMCBI
2010
13 years 9 months ago
2010
Background: Protein sorting is the process that newly synthesized proteins are transported to their target locations within or outside of the cell. This process is precisely regul...