Computational Biology

52

ISMB
1998

193views Computational Biology» more ISMB 1998»

Identification of Divergent Functions in Homologous Proteins by Induction over Conserved Modules

14 years 1 months ago

Homologousproteins do not necessarily exhibit identical biochemicalfunction. Despitethis fact, local or global sequence similarity is widely used as an indication of functional id...

Imran Shah, Lawrence Hunter

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37

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ISMB
1998

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A Surface Measure for Probabilistic Structural Computations

14 years 1 months ago

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Computingthree-dimensional structures from sparse experimentalconstraints requires methodsfor combining heterogeneoussourcesof information,such as distances, angles, andmeasuresof...

Jeanette P. Schmidt, Cheng Che Chen, Jonathan L. C...

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40

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ISMB
1998

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Sequence Assembly Validation by Multiple Restriction Digest Fragment Coverage Analysis

14 years 1 months ago

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DNA sequence analysis depends on the accurate assembly of fragment reads for the determination of a consensus sequence. This report examines the possibility of analyzing multiple,...

Eric C. Rouchka, David J. States

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42

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ISMB
1998

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A Hidden Markov Model for Predicting Transmembrane Helices in Protein Sequences

14 years 1 months ago

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A novel method to model and predict the location and orientation of alpha helices in membrane- spanning proteins is presented. It is based on a hidden Markov model (HMM) with an a...

Erik L. L. Sonnhammer, Gunnar von Heijne, Anders K...

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39

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ISMB
1998

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Bayesian Protein Family Classifier

14 years 1 months ago

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A Bayesian procedure for the simultaneous alignment and classification of sequences into subclasses is described. This Gibbs sampling algorithm iterates between an alignment step ...

Kunbin Qu, Lee Ann McCue, Charles E. Lawrence

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29

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ISMB
1998

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Phylogenetic Inference in Protein Superfamilies: Analysis of SH2 Domains

14 years 1 months ago

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This workfocuses on the inference of evolutionary relationships in protein superfamilies, and the uses of these relationships to identify keypositions in the structure, to infer a...

Kimmen Sjölander

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33

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ISMB
1998

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Segment-Based Scores for Pairwise and Multiple Sequence Alignments

14 years 1 months ago

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Burkhard Morgenstern, William R. Atchley, Klaus Ha...

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32

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ISMB
1998

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Prediction of Signal Peptides and Signal Anchors by a Hidden Markov Model

14 years 1 months ago

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A hidden Markov model of signal peptides has been developed. It contains submodels for the N-terminal part, the hydrophobic region, and the region around the cleavage site. For kn...

Henrik Nielsen, Anders Krogh

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28

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ISMB
1998

88views Computational Biology» more ISMB 1998»

Modeling Protein Homopolymeric Repeats: Possible Polyglutamine Structural Motifs for Huntington's Disease

14 years 1 months ago

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Wedescribe a prototype system (Poly-X) for assisting an expert user in modelingprotein repeats. Poly-X reduces the large numberof degrees of freedomrequired to specify a protein m...

Richard H. Lathrop, Malcolm S. Casale, Douglas J. ...

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23

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ISMB
1998

88views Computational Biology» more ISMB 1998»

Hierarchical Minimization with Distance and Angle Constraints

14 years 1 months ago