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: We adapt a combinatorial optimization algorithm, extremal optimization (EO), for the search problem in computational protein design. This algorithm takes advantage of the knowled...
Abstract. We explore a new general-purpose heuristic for nding highquality solutions to hard optimization problems. The method, called extremal optimization, is inspired by self-or...
Stefan Boettcher, Allon G. Percus, Michelangelo Gr...
The protein folding problem consists of predicting the functional (native) structure of the protein given its linear sequence of amino acids. Despite extensive progress made in un...