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BMCBI
2004
90views more  BMCBI 2004»
14 years 12 days ago
Haplotype frequency estimation error analysis in the presence of missing genotype data
Background: Increasingly researchers are turning to the use of haplotype analysis as a tool in population studies, the investigation of linkage disequilibrium, and candidate gene ...
Enda D. Kelly, Fabian Sievers, Ross McManus
BIOINFORMATICS
2004
83views more  BIOINFORMATICS 2004»
14 years 12 days ago
Haplotypes histories as pathways of recombinations
Motivation: The diversity of a haplotype, represented as a string of polymorphic sites along a DNA sequence, increases exponentially with the number of sites if recombinations are...
Nadia El-Mabrouk, Damian Labuda
BMCBI
2005
88views more  BMCBI 2005»
14 years 13 days ago
Analysis of concordance of different haplotype block partitioning algorithms
Background: Different classes of haplotype block algorithms exist and the ideal dataset to assess their performance would be to comprehensively re-sequence a large genomic region ...
Amit R. Indap, Gabor T. Marth, Craig A. Struble, P...
IJAIT
2008
107views more  IJAIT 2008»
14 years 16 days ago
Haplotype Inference with Boolean Satisfiability
One of the main topics of research in genomics is determining the relevance of mutations, described in haplotype data, as causes of some genetic diseases. However, due to technolo...
Inês Lynce, João Marques-Silva
BMCBI
2006
95views more  BMCBI 2006»
14 years 18 days ago
Estimate haplotype frequencies in pedigrees
Background: Haplotype analysis has gained increasing attention in the context of association studies of disease genes and drug responsivities over the last years. The potential us...
Qiangfeng Zhang, YuZhong Zhao, Guoliang Chen, Yun ...
CONSTRAINTS
2008
78views more  CONSTRAINTS 2008»
14 years 19 days ago
Boosting Haplotype Inference with Local Search
Abstract. A very challenging problem in the genetics domain is to infer haplotypes from genotypes. This process is expected to identify genes affecting health, disease and response...
Inês Lynce, João Marques-Silva, Steve...
BMCBI
2007
95views more  BMCBI 2007»
14 years 20 days ago
Haplotype-based score test for linkage in nuclear families
Background: To look for genetic linkage between angiotensin-I converting enzyme(ACE) gene and hypertension in a Korean adolescent cohort, we developed a powerful test using the co...
Chung Mo Nam, Dae Ryong Kang, Jinheum Kim
BMCBI
2007
165views more  BMCBI 2007»
14 years 20 days ago
Direct maximum parsimony phylogeny reconstruction from genotype data
Background: Maximum parsimony phylogenetic tree reconstruction from genetic variation data is a fundamental problem in computational genetics with many practical applications in p...
Srinath Sridhar, Fumei Lam, Guy E. Blelloch, R. Ra...
AAAI
2006
14 years 1 months ago
Efficient Haplotype Inference with Boolean Satisfiability
One of the main topics of research in genomics is determining the relevance of mutations, described in haplotype data, as causes of some genetic diseases. However, due to technolo...
Inês Lynce, João Marques-Silva
CPM
2004
Springer
145views Combinatorics» more  CPM 2004»
14 years 6 months ago
Computational Problems in Perfect Phylogeny Haplotyping: Xor-Genotypes and Tag SNPs
The perfect phylogeny model for haplotype evolution has been successfully applied to haplotype resolution from genotype data. In this study we explore the application of the perfe...
Tamar Barzuza, Jacques S. Beckmann, Ron Shamir, It...