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JCB
2002
93views more  JCB 2002»
13 years 11 months ago
Unfolding of Microarray Data
The use of DNA microarrays for the analysis of complex biological samples is becoming a mainstream part of biomedical research. One of the most commonly used methods compares the ...
Andrew B. Goryachev, Pascale F. Macgregor, Aled M....
JCB
2002
74views more  JCB 2002»
13 years 11 months ago
Using Substitution Matrices to Estimate Probability Distributions for Biological Sequences
Accurately estimating probabilities from observations is important for probabilistic-based approaches to problems in computational biology. In this paper we present a biologically...
Eleazar Eskin, William Stafford Noble, Yoram Singe...
JCB
2002
160views more  JCB 2002»
13 years 11 months ago
Inference from Clustering with Application to Gene-Expression Microarrays
There are many algorithms to cluster sample data points based on nearness or a similarity measure. Often the implication is that points in different clusters come from different u...
Edward R. Dougherty, Junior Barrera, Marcel Brun, ...
JCB
2002
108views more  JCB 2002»
13 years 11 months ago
Fast and Accurate Phylogeny Reconstruction Algorithms Based on the Minimum-Evolution Principle
This paper investigates the standard ordinary least-squares version 24 and the balanced version 20 of the minimum evolution principle. For the standard version, we provide a greedy...
Richard Desper, Olivier Gascuel