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BMCBI
2008
92views more  BMCBI 2008»
14 years 6 days ago
A semiparametric modeling framework for potential biomarker discovery and the development of metabonomic profiles
Background: The discovery of biomarkers is an important step towards the development of criteria for early diagnosis of disease status. Recently electrospray ionization (ESI) and ...
Samiran Ghosh, David F. Grant, Dipak K. Dey, Denni...
BMCBI
2010
193views more  BMCBI 2010»
14 years 6 days ago
MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data
Background: Mass spectrometry (MS) coupled with online separation methods is commonly applied for differential and quantitative profiling of biological samples in metabolomic as w...
Tomás Pluskal, Sandra Castillo, Alejandro V...
BMCBI
2008
92views more  BMCBI 2008»
14 years 6 days ago
OpenMS - An open-source software framework for mass spectrometry
Background: Mass spectrometry is an essential analytical technique for high-throughput analysis in proteomics and metabolomics. The development of new separation techniques, preci...
Marc Sturm, Andreas Bertsch, Clemens Gröpl, A...
BMCBI
2008
106views more  BMCBI 2008»
14 years 6 days ago
Comparison of normalisation methods for surface-enhanced laser desorption and ionisation (SELDI) time-of-flight (TOF) mass spect
Background: Mass spectrometry for biological data analysis is an active field of research, providing an efficient way of high-throughput proteome screening. A popular variant of m...
Wouter Meuleman, Judith Y. M. N. Engwegen, Marie-C...
BMCBI
2007
127views more  BMCBI 2007»
14 years 6 days ago
The EIPeptiDi tool: enhancing peptide discovery in ICAT-based LC MS/MS experiments
Background: Isotope-coded affinity tags (ICAT) is a method for quantitative proteomics based on differential isotopic labeling, sample digestion and mass spectrometry (MS). The me...
Mario Cannataro, Giovanni Cuda, Marco Gaspari, Ser...
BMCBI
2008
158views more  BMCBI 2008»
14 years 6 days ago
LC-MSsim - a simulation software for liquid chromatography mass spectrometry data
Background: Mass Spectrometry coupled to Liquid Chromatography (LC-MS) is commonly used to analyze the protein content of biological samples in large scale studies. The data resul...
Ole Schulz-Trieglaff, Nico Pfeifer, Clemens Gr&oum...
DAGSTUHL
2007
14 years 1 months ago
Advances in pre-processing and model generation for mass spectrometric data analysis
Abstract. The analysis of complex signals as obtained by mass spectrometric measurements is complicated and needs an appropriate representation of the data. Thereby the kind of pre...
Frank-Michael Schleif
ECCB
2008
IEEE
14 years 1 months ago
Towards de novo identification of metabolites by analyzing tandem mass spectra
Abstract. Mass spectrometry is among the most widely used technologies in proteomics and metabolomics. For metabolites, de novo interpretation of spectra is even more important tha...
Sebastian Böcker, Florian Rasche
GCB
2006
Springer
136views Biometrics» more  GCB 2006»
14 years 3 months ago
Ab Initio Prediction of Molecular Fragments from Tandem Mass Spectrometry Data
: Mass spectrometry is one of the key enabling measurement technologies for systems biology, due to its ability to quantify molecules in small concentrations. Tandem mass spectrome...
Markus Heinonen, Ari Rantanen, Taneli Mielikä...
ICANN
2007
Springer
14 years 4 months ago
Neural Network Approach for Mass Spectrometry Prediction by Peptide Prototyping
In todays bioinformatics, Mass spectrometry (MS) is the key technique for the identification of proteins. A prediction of spectrum peak intensities from pre computed molecular feat...
Alexandra Scherbart, Wiebke Timm, Sebastian Bö...