NAR
1998
14 years 3 days ago
1998
Pfam contains multiple alignments and hidden Markov model based profiles (HMM-profiles) of complete protein domains. The definition of domain boundaries, family members and alignm...
NAR
2000
14 years 7 days ago
2000
Mitochondria, besides their central role in energy metabolism, have recently been found to be involved in a number of basic processes of cell life and to contribute to the pathoge...
BMCBI
2004
14 years 9 days ago
2004
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
BMCBI
2005
14 years 10 days ago
2005
Background: Multiple genome alignment is an important problem in bioinformatics. An important subproblem used by many multiple alignment approaches is that of aligning two multipl...
BMCBI
2007
14 years 14 days ago
2007
Background: Activated Protein C (ProC) is an anticoagulant plasma serine protease which also plays an important role in controlling inflammation and cell proliferation. Several mu...
BMCBI
2007
14 years 14 days ago
2007
Background: High quality multiple alignments are crucial in the transfer of annotation from one genome to another. Multiple alignment methods strive to achieve ever increasing lev...
BMCBI
2006
14 years 15 days ago
2006
Background: Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, d...
BMCBI
2008
14 years 17 days ago
2008
Background: Comparative prediction of RNA structures can be used to identify functional noncoding RNAs in genomic screens. It was shown recently by Babak et al. [BMC Bioinformatic...
BMCBI
2010
14 years 17 days ago
2010
Background: While multiple alignment is the first step of usual classification schemes for biological sequences, alignment-free methods are being increasingly used as alternatives...
ISMB
1993
14 years 1 months ago
1993
A Bayesian method for estimating the amino acid distributions in the states of a hidden Markov model (HMM) for a protein familyor the columns of a multiple alignment of that famil...