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BMCBI
2010
104views more  BMCBI 2010»
13 years 7 months ago
A systematic study of genome context methods: calibration, normalization and combination
Background: Genome context methods have been introduced in the last decade as automatic methods to predict functional relatedness between genes in a target genome using the patter...
Luciana Ferrer, Joseph M. Dale, Peter D. Karp
BMCBI
2007
131views more  BMCBI 2007»
14 years 13 days ago
An improved method for identifying functionally linked proteins using phylogenetic profiles
Background: Phylogenetic profiles record the occurrence of homologs of genes across fully sequenced organisms. Proteins with similar profiles are typically components of protein c...
Shawn Cokus, Sayaka Mizutani, Matteo Pellegrini
BMCBI
2007
80views more  BMCBI 2007»
14 years 17 days ago
A network perspective on the topological importance of enzymes and their phylogenetic conservation
Background: A metabolic network is the sum of all chemical transformations or reactions in the cell, with the metabolites being interconnected by enzyme-catalyzed reactions. Many ...
Wei-chung Liu, Wen-hsien Lin, Andrew J. Davis, Fer...