An essential prerequisite for any systems-level understanding of cellular functions is to correctly uncover and annotate all functional interactions among proteins in the cell. To...
Damian Szklarczyk, Andrea Franceschini, Michael Ku...
Background: Accurate identification of protein domain boundaries is useful for protein structure determination and prediction. However, predicting protein domain boundaries from a...
Protein domains are subunits of proteins that recur throughout the protein world. There are many definitions attempting to capture the essence of a protein domain, and several sys...
Background: It is well known that different species have different protein domain repertoires, and indeed that some protein domains are kingdom specific. This information has not ...
Lachlan James M. Coin, Alex Bateman, Richard Durbi...
Background: Protein domains have long been an ill-defined concept in biology. They are generally described as autonomous folding units with evolutionary and functional independenc...
Ya Zhang, John-Marc Chandonia, Chris H. Q. Ding, S...
We present DAhunter, a web-based server that identifies homologous proteins by comparing domain architectures, the organization of protein domains. A major obstacle in comparison ...
Protein domains are the building blocks of proteins, and their interactions are crucial in forming stable protein-protein interactions (PPI) and take part in many cellular processe...
—Interactions between transcription factors (TFs) are necessary for deciphering the complex mechanisms of transcription regulation in eukaryotes. In this paper, we proposed a nov...
Studies of interactions between protein domains and ligands are important in many aspects such as cellular signaling. We present a knowledge-guided approach for docking protein dom...
Haiyun Lu, Hao Li, Shamima Banu Bte Sm Rashid, Wee...