BMCBI
2006
14 years 24 days ago
2006
Background: Accurate small molecule binding site information for a protein can facilitate studies in drug docking, drug discovery and function prediction, but small molecule bindi...
BMCBI
2006
14 years 24 days ago
2006
Background: Sequence comparison is one of the most prominent tools in biological research, and is instrumental in studying gene function and evolution. The rapid development of hi...
BMCBI
2006
14 years 24 days ago
2006
Background: Both direct and indirect interactions determine molecular recognition of ligands by proteins. Indirect interactions can be defined as effects on recognition controlled...
BMCBI
2006
14 years 24 days ago
2006
Background: Due to the functional importance of intrinsically disordered proteins or protein regions, prediction of intrinsic protein disorder from amino acid sequence has become ...
BMCBI
2006
14 years 24 days ago
2006
Background: We present 2DDB, a bioinformatics solution for storage, integration and analysis of quantitative proteomics data. As the data complexity and the rate with which it is ...
BMCBI
2006
14 years 24 days ago
2006
Background: Monoclonal antibodies are used extensively throughout the biomedical sciences for detection of antigens, either in vitro or in vivo. We, for example, have used them fo...
BMCBI
2006
14 years 24 days ago
2006
Background: Phytochromes are photoreceptors, discovered in plants, that control a wide variety of developmental processes. They have also been found in bacteria and fungi, but for...
BMCBI
2006
14 years 24 days ago
2006
Background: Various experimental techniques yield peptides that are biologically active but have unfavourable pharmacological properties. The design of structurally similar organi...
BMCBI
2006
14 years 24 days ago
2006
Background: Members of a protein family often have highly conserved sequences; most of these sequences carry identical biological functions and possess similar three-dimensional (...
BMCBI
2006
14 years 24 days ago
2006
Background: The main processing pathway for MHC class I ligands involves degradation of proteins by the proteasome, followed by transport of products by the transporter associated...