BMCBI
2010
14 years 17 days ago
2010
Background: The ability to design thermostable proteins is theoretically important and practically useful. Robust and accurate algorithms, however, remain elusive. One critical pr...
BMCBI
2010
14 years 17 days ago
2010
Background: Semantic similarity scores for protein pairs are widely applied in functional genomic researches for finding functional clusters of proteins, predicting protein functi...
BMCBI
2010
14 years 17 days ago
2010
Background: Bacterial infections represent a global health challenge. The identification of novel antibacterial targets for both therapy and vaccination is needed on a constant ba...
BMCBI
2010
14 years 17 days ago
2010
Background: We analysed 48 non-redundant antibiotic target proteins from all bacteria, 22 antibiotic target proteins from E. coli only and 4243 non-drug targets from E. coli to id...
BMCBI
2010
14 years 17 days ago
2010
Background: Natively unfolded proteins lack a well defined three dimensional structure but have important biological functions, suggesting a re-assignment of the structure-functio...
BMCBI
2010
14 years 17 days ago
2010
Background: The hierarchical and partially redundant nature of protein structures justifies the definition of frequently occurring conformations of short fragments as `states'...
BMCBI
2010
14 years 17 days ago
2010
Background: A protein binding hot spot is a small cluster of residues tightly packed at the center of the interface between two interacting proteins. Though a hot spot constitutes...
BMCBI
2010
14 years 17 days ago
2010
Background: Various high throughput methods are available for detecting regulations at the level of transcription, translation or posttranslation (e.g. phosphorylation). Integrati...
BMCBI
2010
14 years 17 days ago
2010
Background: We present a statistical method of analysis of biological networks based on the exponential random graph model, namely p2-model, as opposed to previous descriptive app...
BIOINFORMATICS
2008
14 years 17 days ago
2008
Motivation: Cellular processes often hinge upon specific interactions among proteins, and knowledge of these processes at a system level constitutes a major goal of proteomics. In...