Protein interactions and complexes are major components of biological systems. Recent genome-wide applications of tandem affinity purification (TAP) in yeast have increased signifi...
Comparative analysis of protein networks has proven to be a powerful approach for elucidating network structure and predicting protein function and interaction. A fundamental chall...
Abstract. In engineering protein variants by constructing and screening combinatorial libraries of chimeric proteins, two complementary and competing goals are desired: the new pro...
A central challenge in systems biology is the reconstruction of biological networks from high-throughput data sets. A particularly difficult case of this is the inference of dynami...
Michael Baym, Chris Bakal, Norbert Perrimon, Bonni...
High-accuracy protein structure modeling demands accurate and very fast side chain prediction since such a procedure must be repeatedly called at each step of structure refinement....
A major hindrance to studies of microbial diversity has been that the vast majority of microbes cannot be cultured in the laboratory and thus are not amenable to traditional method...
A key problem of interest to biologists and medical researchers is the selection of a subset of queries or treatments that provide maximum utility for a population of targets. For ...
Delbert Dueck, Brendan J. Frey, Nebojsa Jojic, Vla...