Quantum information processing technology is in its pioneering stage and no proficient method for synthesizing quantum circuits has been introduced so far. This paper introduces an effective analysis and synthesis framework for quantum logic circuits. The proposed synthesis algorithm and flow can generate a quantum circuit using the most basic quantum operators, i.e., the rotation and controlled-rotation primitives. The paper introduces the notion of quantum factored forms and presents a canonical and concise representation of quantum logic circuits in the form of quantum decision diagrams (QDD’s), which are amenable to efficient manipulation and optimization including recursive unitary functional bi-decomposition. This paper concludes by presenting the QDD-based algorithm for automatic synthesis of quantum circuits.