Identifying Simple Discriminatory Gene Vectors with an Information Theory Approach

In the feature selection of cancer classification problems, many existing methods consider genes individually by choosing the top genes which have the most significant signal-to-noise statistic or correlation coefficient. However the information of the class distinction provided by such genes may overlap intensively, since their gene expression patterns are similar. The redundancy of including many genes with similar gene expression patterns results in highly complex classifiers. According to the principle of Occam’s razor, simple models are preferable to complex ones, if they can produce comparable prediction performances to the complex ones. In this paper, we introduce a new method to learn accurate and low-complexity classifiers from gene expression profiles. In our method, we use mutual information to measure the relation between a set of genes, called gene vectors, and the class attribute of the samples. The gene vectors are in higher-dimensional spaces than individual ge...

• Type: Conference
• Year: 2005
• Where: CSB
• Authors: Zheng Yun, Kwoh Chee Keong
• Keywords: Bioinformatics, CSB 2005, Gene Expression, Gene Expression Patterns, Gene Vectors