This paper suggests a practical “hybrid” synthesis methodology which integrates designer-derived analytical models for system-level description with simulation-based models at the circuit level. We show how to optimize stageresolution to minimize the power in a pipelined ADC. Exploration (via detailed synthesis) of several ADC configurations is used to show that a 4-3-2… resolution distribution uses the least power for a 13-bit 40 MSPS converter in a 0.25 µm CMOS process.