This paper addresses the problem of camera calibration from spheres. By studying the relationship between the dual images of spheres and that of the absolute conic, a linear solution has been derived from a recently proposed non-linear semi-definite approach. However, experiments show that this approach is quite sensitive to noise. In order to overcome this problem, a second approach has been proposed, where the orthogonal calibration relationship is obtained by regarding any two spheres as a surface of revolution. This allows a camera to be fully calibrated from an image of three spheres. Besides, a conic homography is derived from the imaged spheres, and from its eigenvectors the orthogonal invariants can be computed directly. Experiments on synthetic and real data show the practicality of such an approach.