Traditionally, application specific computations have been focusing on numerically intensive data manipulation. Modern communications and DSP applications, such as WWW, interactive high resolution TV, video-on-demand, and wireless communications, however, are increasingly more data management oriented. At the same time, the technological trends indicate that magnetic disk system performance is rapidly becoming a principal component in overall system behavior. In this paper, we initiate behavioral and system level research in synthesis of disk-based application specific system by introducing cost and throughput optimization problems for synthesis of disk-based application specific systems (DASS). We formulate, establish computational complexity, and develop efficient optimization algorithms for data assignment on a single and multiple disks so that the seek time overhead is minimized. Extensive experimental results clearly indicate the importance of the synthesis problem and effectiven...