In silico white blood cell: mechanisms underlying leukocyte rolling and adhesion during inflammation

We have used the synthetic modeling method to construct a multilevel, agent oriented, in silico analogue of an in vitro experimental system for studying leukocyte rolling, activation, and adhesion during inflammatory conditions. We specify capabilities that the envisioned analogues must have to achieve long-term goals. Here, we report progress towards our goal of using variants of this model as experimental systems for exploring the potential role of hypothesized mechanisms that are thought to mediate leukocyte rolling, activation, and adhesion. We focus initially on diffusion and clustering events of the LFA-1 integrin receptor on the leukocyte membrane during rolling and adhesion.

• Type: Conference
• Year: 2008
• Where: SPRINGSIM
• Authors: Jonathan Tang, C. Anthony Hunt
• Keywords: Leukocyte, Modeling And Simulation, Silico Analogue, SPRINGSIM 2008, Synthetic Modeling Method