Many algorithms for processing probabilistic networks are dependent on the topological properties of the problem's structure. Such algorithmse.g., clustering, conditioning are e ective only if the problem has a sparse graph captured by parameters such as tree width and cycle-cutset size. In this paper we initiate a study to determine the potential of structure-based algorithms in real-life applications. We analyze empirically the structural properties of problems coming from the circuit diagnosis domain. Speci cally, we locate those properties that capture the e ectiveness of clustering and conditioningas well as of a family of conditioning+clustering algorithms designed to gradually trade space for time. We perform our analysis on 11 benchmark circuits widely used in the testing community. We also report on the effect of ordering heuristics on tree-clustering and show that, on our benchmarks, the wellknown max-cardinality ordering is substantially inferior to an ordering called ...