PhenoFam-gene set enrichment analysis through protein structural information

Background: With the current technological advances in high-throughput biology, the necessity to develop tools that help to analyse the massive amount of data being generated is evident. A powerful method of inspecting large-scale data sets is gene set enrichment analysis (GSEA) and investigation of protein structural features can guide determining the function of individual genes. However, a convenient tool that combines these two features to aid in highthroughput data analysis has not been developed yet. In order to fill this niche, we developed the user-friendly, webbased application, PhenoFam. Results: PhenoFam performs gene set enrichment analysis by employing structural and functional information on families of protein domains as annotation terms. Our tool is designed to analyse complete sets of results from quantitative high-throughput studies (gene expression microarrays, functional RNAi screens, etc.) without prior prefiltering or hits-selection steps. PhenoFam utilizes Ensem...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Maciej Paszkowski-Rogacz, Mikolaj Slabicki, M. Teresa Pisabarro, Frank Buchholz
• Keywords: BMCBI 2010, Enrichment Analysis, Gene, Protein