GeneMesh: a web-based microarray analysis tool for relating differentially expressed genes to MeSH terms

Background: An important objective of DNA microarray-based gene expression experimentation is determining interrelationships that exist between differentially expressed genes and biological processes, molecular functions, cellular components, signaling pathways, physiologic processes and diseases. Results: Here we describe GeneMesh, a web-based program that facilitates analysis of DNA microarray gene expression data. GeneMesh relates genes in a query set to categories available in the Medical Subject Headings (MeSH) hierarchical index. The interface enables hypothesis driven relational analysis to a specific MeSH subcategory (e.g., Cardiovascular System, Genetic Processes, Immune System Diseases etc.) or unbiased relational analysis to broader MeSH categories (e.g., Anatomy, Biological Sciences, Disease etc.). Genes found associated with a given MeSH category are dynamically linked to facilitate tabular and graphical depiction of Entrez Gene information, Gene Ontology information, KEG...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Saurin D. Jani, Gary L. Argraves, Jeremy L. Barth, W. Scott Argraves
• Keywords: BMCBI 2010, Gene, Gene Expression, Mesh