BioSAVE: Display of scored annotation within a sequence context

Background: Visualization of sequence annotation is a common feature in many bioinformatics tools. For many applications it is desirable to restrict the display of such annotation according to a score cutoff, as biological interpretation can be difficult in the presence of the entire data. Unfortunately, many visualisation solutions are somewhat static in the way they handle such score cutoffs. Results: We present BioSAVE, a sequence annotation viewer with on-the-fly selection of visualisation thresholds for each feature. BioSAVE is a versatile OS X program for visual display of scored features (annotation) within a sequence context. The program reads sequence and additional supplementary annotation data (e.g., position weight matrix matches, conservation scores, structural domains) from a variety of commonly used file formats and displays them graphically. Onscreen controls then allow for live customisation of these graphics, including on-thefly selection of visualisation thresholds ...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Richard F. Pollock, Boris Adryan
• Keywords: Annotation, BMCBI 2008, Score Cutoffs, Sequence Annotation