Gene and pathway identification with Lp penalized Bayesian logistic regression

Background: Identifying genes and pathways associated with diseases such as cancer has been a subject of considerable research in recent years in the area of bioinformatics and computational biology. It has been demonstrated that the magnitude of differential expression does not necessarily indicate biological significance. Even a very small change in the expression of particular gene may have dramatic physiological consequences if the protein encoded by this gene plays a catalytic role in a specific cell function. Moreover, highly correlated genes may function together on the same pathway biologically. Finally, in sparse logistic regression with Lp (p < 1) penalty, the degree of the sparsity obtained is determined by the value of the regularization parameter. Usually this parameter must be carefully tuned through cross-validation, which is time consuming. Results: In this paper, we proposed a simple Bayesian approach to integrate the regularization parameter out analytically using...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Zhenqiu Liu, Ronald B. Gartenhaus, Ming Tan, Feng Jiang, Xiaoli Jiao
• Keywords: BMCBI 2008, Correlated Genes, Gene, Regularization Parameter