The pairwise disconnectivity index as a new metric for the topological analysis of regulatory networks

Background: Currently, there is a gap between purely theoretical studies of the topology of large bioregulatory networks and the practical traditions and interests of experimentalists. While the theoretical approaches emphasize the global characterization of regulatory systems, the practical approaches focus on the role of distinct molecules and genes in regulation. To bridge the gap between these opposite approaches, one needs to combine 'general' with 'particular' properties slate abstract topological features of large systems into testable functional characteristics of individual components. Here, we propose a new topological parameter

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Anatolij Potapov, Björn Goemann, Edgar Wingender
• Keywords: BMCBI 2008, Individual Element, Large Bioregulatory Networks, Pairwise Disconnectivity Index