Comparison study of microarray meta-analysis methods

Background: Meta-analysis methods exist for combining multiple microarray datasets. However, there are a wide range of issues associated with microarray meta-analysis and a limited ability to compare the performance of different meta-analysis methods. Results: We compare eight meta-analysis methods, five existing methods, two naive methods and a novel approach (mDEDS). Comparisons are performed using simulated data and two biological case studies with varying degrees of meta-analysis complexity. The performance of meta-analysis methods is assessed via ROC curves and prediction accuracy where applicable. Conclusions: Existing meta-analysis methods vary in their ability to perform successful meta-analysis. This success is very dependent on the complexity of the data and type of analysis. Our proposed method, mDEDS, performs competitively as a meta-analysis tool even as complexity increases. Because of the varying abilities of compared meta-analysis methods, care should be taken when con...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Anna Campain, Yee Hwa Yang
• Keywords: BMCBI 2010, Meta-analysis, Meta-analysis Methods, Microarray Meta-analysis