Chromhome: A rich internet application for accessing comparative chromosome homology maps

Background: Comparative genomics has become a significant research area in recent years, following the availability of a number of sequenced genomes. The comparison of genomes is of great importance in the analysis of functionally important genome regions. It can also be used to understand the phylogenetic relationships of species and the mechanisms leading to rearrangement of karyotypes during evolution. Many species have been studied at the cytogenetic level by cross species chromosome painting. With the large amount of such information, it has become vital to computerize the data and make them accessible worldwide. Chromhome http:// www.chromhome.org is a comprehensive web application that is designed to provide cytogenetic comparisons among species and to fulfil this need. Results: The Chromhome application architecture is multi-tiered with an interactive client layer, business logic and database layers. Enterprise java platform with open source framework OpenLaszlo is used to imp...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Sridevi Nagarajan, Willem Rens, James Stalker, Tony Cox, Malcolm A. Ferguson-Smith
• Keywords: BMCBI 2008, Chromhome Application, Genome, Significant Research Area