Mining phenotypes for gene function prediction

Background: Health and disease of organisms are reflected in their phenotypes. Often, a genetic component to a disease is discovered only after clearly defining its phenotype. In the past years, many technologies to systematically generate phenotypes in a high-throughput manner, such as RNA interference or gene knock-out, have been developed and used to decipher functions for genes. However, there have been relatively few efforts to make use of phenotype data beyond the single genotype-phenotype relationships. Results: We present results on a study where we use a large set of phenotype data

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Philip Groth, Bertram Weiss, Hans-Dieter Pohlenz, Ulf Leser
• Keywords: Annotation, BMCBI 2008, Gene, Phenotype