SNPs3D: Candidate gene and SNP selection for association studies

Background: The relationship between disease susceptibility and genetic variation is complex, and many different types of data are relevant. We describe a web resource and database that provides and integrates as much information as possible on disease/gene relationships at the molecular level. Description: The resource http://www.SNPs3D.org has three primary modules. One module identifies which genes are candidates for involvement in a specified disease. A second module provides information about the relationships between sets of candidate genes. The third module analyzes the likely impact of non-synonymous SNPs on protein function. Disease/candidate gene relationships and gene-gene relationships are derived from the literature using simple but effective text profiling. SNP/protein function relationships are derived by two methods, one using principles of protein structure and stability, the other based on sequence conservation. Entries for each gene include a number of links to othe...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Peng Yue, Eugene Melamud, John Moult
• Keywords: BMCBI 2006, Candidate Genes, Disease, Gene Relationships