NOXclass: prediction of protein-protein interaction types

Background: Structural models determined by X-ray crystallography play a central role in understanding protein-protein interactions at the molecular level. Interpretation of these models requires the distinction between non-specific crystal packing contacts and biologically relevant interactions. This has been investigated previously and classification approaches have been proposed. However, less attention has been devoted to distinguishing different types of biological interactions. These interactions are classified as obligate and non-obligate according to the effect of the complex formation on the stability of the protomers. So far no automatic classification methods for distinguishing obligate, non-obligate and crystal packing interactions have been made available. Results: Six interface properties have been investigated on a dataset of 243 protein interactions. The six properties have been combined using a support vector machine algorithm, resulting in NOXclass, a classifier for ...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Hongbo Zhu, Francisco S. Domingues, Ingolf Sommer, Thomas Lengauer
• Keywords: BMCBI 2006, Non-specific Crystal Packing, Protein-protein Interactions, Relevant Interactions