A joint model of regulatory and metabolic networks

Background: Gene regulation and metabolic reactions are two primary activities of life. Although many works have been dedicated to study each system, the coupling between them is less well understood. To bridge this gap, we propose a joint model of gene regulation and metabolic reactions. Results: We integrate regulatory and metabolic networks by adding links specifying the feedback control from the substrates of metabolic reactions to enzyme gene expressions. We adopt two alternative approaches to build those links: inferring the links between metabolites and transcription factors to fit the data or explicitly encoding the general hypotheses of feedback control as links between metabolites and enzyme expressions. A perturbation data is explained by paths in the joint network if the predicted response along the paths is consistent with the observed response. The consistency requirement for explaining the perturbation data imposes constraints on the attributes in the network such as th...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Chen-Hsiang Yeang, Martin Vingron
• Keywords: BMCBI 2006, Feedback Control, Gene Regulation, Metabolic Reactions