PageMan: An interactive ontology tool to generate, display, and annotate overview graphs for profiling experiments

Background: Microarray technology has become a widely accepted and standardized tool in biology. The first microarray data analysis programs were developed to support pair-wise comparison. However, as microarray experiments have become more routine, large scale experiments have become more common, which investigate multiple time points or sets of mutants or transgenics. To extract biological information from such high-throughput expression data, it is necessary to develop efficient analytical platforms, which combine manually curated gene ontologies with efficient visualization and navigation tools. Currently, most tools focus on a few limited biological aspects, rather than offering a holistic, integrated analysis. Results: Here we introduce PageMan, a multiplatform, user-friendly, and stand-alone software tool that annotates, investigates, and condenses high-throughput microarray data in the context of functional ontologies. It includes a GUI tool to transform different ontologies i...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Björn Usadel, Axel Nagel, Dirk Steinhauser, Yves Gibon, Oliver E. Bläsing, Henning Redestig, Nese Sreenivasulu, Leonard Krall, Matthew A. Hannah, Fabien Poree, Alisdair R. Fernie, Mark Stitt
• Keywords: BMCBI 2006, Microarray Data, Multiple Time Points, Tool