Background: The Immune Epitope Database and Analysis Resource (IEDB) is dedicated to capturing, housing and analyzing complex immune epitope related data http:// www.immuneepitope.org. Description: To identify and extract relevant data from the scientific literature in an efficient and accurate manner, novel processes were developed for manual and semi-automated annotation. Conclusion: Formalized curation strategies enable the processing of a large volume of contextdependent data, which are now available to the scientific community in an accessible and transparent format. The experiences described herein are applicable to other databases housing complex biological data and requiring a high level of curation expertise. Background Many aspects of biological sciences have profited from the recent advances in the field of bioinformatics. New computational methodologies and tools allow researchers to capture, store, analyze and model large volumes of data, thereby dramatically affecting th...