Sciweavers

CANDC
2007
ACM

Chromosome segregation in Escherichia coli division: A free energy-driven string model

13 years 11 months ago
Chromosome segregation in Escherichia coli division: A free energy-driven string model
Although the mechanisms of eukaryotic chromosome segregation and cell division have been elucidated to a certain extent, those for bacteria remain largely unknown. Here we present a computational string model for simulating the dynamics of Escherichia coli chromosome segregation. A novel thermal-average force field accounting for stretching, bending, volume exclusion, friction and random fluctuation is introduced. A Langevin equation is used to simulate the chromosome structural changes. The mechanism of chromosome segregation is thereby postulated as a result of free energy-driven structural optimization with replication introduced chromosomal mass increase. Predictions of the model agree well with observations of fluorescence labeled chromosome loci movement in living cells. The results demonstrate the possibility of a mechanism of chromosome segregation that does not involve cytoskeletal guidance or advanced apparatus in an E. coli cell. The model also shows that DNA condensatio...
Jianmiao Fan, Kagan Tuncay, Peter J. Ortoleva
Added 12 Dec 2010
Updated 12 Dec 2010
Type Journal
Year 2007
Where CANDC
Authors Jianmiao Fan, Kagan Tuncay, Peter J. Ortoleva
Comments (0)