Computed tomography (CT) images have been widely used for diagnosis of liver disease and volume measurement for liver surgery or transplantation. Automatic liver segmentation and volume measurement based on the segmentation are the most essential parts in computer-aided diagnosis for liver CT as well as computer-aided surgery. However, liver segmentation, in general, has been performed by outlining the medical image manually or segmenting CT images semi-automatically because surface features of the liver and partial-volume effects make automatic discrimination from other adjacent organs or tissues very difficult. Accordingly, in this paper, we propose a new approach to automatic segmentation of the liver for volume measurement in sequential CT images. Our method analyzes the intensity distribution of several abdominal CT samples and exploits a priori knowledge, such as CT numbers and location of the liver to identify coherent regions that correspond to the liver. The proposed scheme u...