Comparison of codon usage measures and their applicability in prediction of microbial gene expressivity

Background: There are a number of methods (also called: measures) currently in use that quantify codon usage in genes. These measures are often influenced by other sequence properties, such as length. This can introduce strong methodological bias into measurements; therefore we attempted to develop a method free from such dependencies. One of the common applications of codon usage analyses is to quantitatively predict gene expressivity. Results: We compared the performance of several commonly used measures and a novel method we introduce in this paper

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: Fran Supek, Kristian Vlahovicek
• Keywords: BMCBI 2005, Codon, Expression Levels, Gene Expression Levels