PASS2: an automated database of protein alignments organised as structural superfamilies

Background: The functional selection and three-dimensional structural constraints of proteins in nature often relates to the retention of significant sequence similarity between proteins of similar fold and function despite poor sequence identity. Organization of structure-based sequence alignments for distantly related proteins, provides a map of the conserved and critical regions of the protein universe that is useful for the analysis of folding principles, for the evolutionary unification of protein families and for maximizing the information return from experimental structure determination. The Protein Alignment organised as Structural Superfamily (PASS2) database represents continuously updated, structural alignments for evolutionary related, sequentially distant proteins. Description: An automated and updated version of PASS2 is, in direct correspondence with

• Type: Journal
• Year: 2004
• Where: BMCBI
• Authors: Anirban Bhaduri, Ganesan Pugalenthi, Ramanathan Sowdhamini
• Keywords: BMCBI 2004, Proteins, Structure-based Sequence Alignments, Three-dimensional Structural Constraints