A database for G proteins and their interaction with GPCRs

Background: G protein-coupled receptors (GPCRs) transduce signals from extracellular space into the cell, through their interaction with G proteins, which act as switches forming heterotrimers composed of different subunits (,,). The subunit of the G protein is responsible for the recognition of a given GPCR. Whereas specialised resources for GPCRs, and other groups of receptors, are already available, currently, there is no publicly available database focusing on G Proteins and containing information about their coupling specificity with their respective receptors. Description: gpDB is a publicly accessible G proteins/GPCRs relational database. Including species homologs, the database contains detailed information for 418 G protein monomers (272 G, 87 G and 59 G) and 2782 GPCRs sequences belonging to families with known coupling to G proteins. The GPCRs and the G proteins are classified according to a hierarchy of different classes, families and sub-families, based on extensive lite...

• Type: Journal
• Year: 2004
• Where: BMCBI
• Authors: Antigoni L. Elefsinioti, Pantelis G. Bagos, Ioannis C. Spyropoulos, Stavros J. Hamodrakas
• Keywords: BMCBI 2004, Coupling Specificity, Database, Proteins