PhyME: A probabilistic algorithm for finding motifs in sets of orthologous sequences

Background: This paper addresses the problem of discovering transcription factor binding sites in heterogeneous sequence data, which includes regulatory sequences of one or more genes, as well as their orthologs in other species. Results: We propose an algorithm that integrates two important aspects of a motif's significance

• Type: Journal
• Year: 2004
• Where: BMCBI
• Authors: Saurabh Sinha, Mathieu Blanchette, Martin Tompa
• Keywords: BMCBI 2004, Heterogeneous Sequence Data, Regulatory Sequences, Sequences