New insights into protein-protein interaction data lead to increased estimates of the S. cerevisiae interactome size

Background: As protein interactions mediate most cellular mechanisms, protein-protein interaction networks are essential in the study of cellular processes. Consequently, several large-scale interactome mapping projects have been undertaken, and protein-protein interactions are being distilled into databases through literature curation; yet protein-protein interaction data are still far from comprehensive, even in the model organism Saccharomyces cerevisiae. Estimating the interactome size is important for evaluating the completeness of current datasets, in order to measure the remaining efforts that are required. Results: We examined the yeast interactome from a new perspective, by taking into account how thoroughly proteins have been studied. We discovered that the set of literature-curated protein-protein interactions is qualitatively different when restricted to proteins that have received extensive attention from the scientific community. In particular, these interactions are les...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Laure Sambourg, Nicolas Thierry-Mieg
• Keywords: BMCBI 2010, Business, Interactome, Interactome Size, Protein-protein Interactions