miRGator v2.0 : an integrated system for functional investigation of microRNAs

miRGator is an integrated database of microRNA (miRNA)-associated gene expression, target prediction, disease association and genomic annotation, which aims to facilitate functional investigation of miRNAs. The recent version of miRGator v2.0 contains information about (i) human miRNA expression profiles under various experimental conditions, (ii) paired expression profiles of both mRNAs and miRNAs, (iii) gene expression profiles under miRNA-perturbation (e.g. miRNA knockout and overexpression), (iv) known/predicted miRNA targets and (v) miRNA-disease associations. In total, >8000 miRNA expression profiles, 300 miRNA-perturbed gene expression profiles and 2000 mRNA expression profiles are compiled with manually curated annotations on disease, tissue type and perturbation. By integrating these data sets, a series of novel associations (miRNA– miRNA, miRNA–disease and miRNA–target) is extracted via shared features. For example, differentially expressed genes (DEGs) after miRN...

• Type: Journal
• Year: 2011
• Where: NAR
• Authors: Sooyoung Cho, Yukyung Jun, Sanghyun Lee, Hyung-Seok Choi, Sungchul Jung, Youngjun Jang, Charny Park, Sangok Kim, Sanghyuk Lee, Wankyu Kim
• Keywords: Computer Vision, Expression Profiles, MiRNA, MiRNA Expression, NAR 2011