A distributed, collaborative intelligent agent system approach for proactive postmarketing drug safety surveillance

Discovering unknown adverse drug reactions (ADRs) in postmarketing surveillance as early as possible is of great importance. The current approach to postmarketing surveillance primarily relies on spontaneous reporting. It is a passive surveillance system and limited by gross underreporting (<10% reporting rate), latency, and inconsistent reporting. We propose a novel team-based intelligent agent software system approach for proactively monitoring and detecting potential ADRs of interest using electronic patient records. We designed such a system and named it ADRMonitor. The intelligent agents, operating on computers located in different places, are capable of continuously and autonomously collaborating with each other and assisting the human users (e.g., the food and drug administration (FDA), drug safety professionals, and physicians). The agents should enhance current systems and accelerate early ADR identification. To evaluate the performance of the ADRMonitor with respect to the...

• Type: Journal
• Year: 2010
• Where: TITB
• Authors: Yanqing Ji, Hao Ying, Margo S. Farber, John Yen, Peter Dews, Richard E. Miller, R. Michael Massanari
• Keywords: Drug, Education, Spontaneous Reporting, Spontaneous Reporting Approach, TITB 2010