TITB
2010
13 years 7 months ago
2010
Discovering unknown adverse drug reactions (ADRs) in postmarketing surveillance as early as possible is of great importance. The current approach to postmarketing surveillance prim...
NCA
2007
IEEE
14 years 2 days ago
2007
IEEE
Designing drugs is a current problem in the pharmaceutical research. By designing a drug we mean to choose some variables of drug formulation (inputs), for obtaining optimal charac...
NAR
2006
14 years 15 days ago
2006
DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical)data withcomprehensive drug target (i.e.protein) information. The database ...
NAR
2006
14 years 15 days ago
2006
Although tremendous effort has been put into synthetic libraries, most drugs on the market are still 10 natural compounds or derivatives thereof. There are encyclopaedias of natur...
NAR
2006
14 years 15 days ago
2006
G-protein coupled receptors (GPCRs) represent one of the most important families of drug targets in pharmaceutical development. GPCR-LIgand DAtabase (GLIDA) is a novel public GPCR...
JIB
2006
14 years 16 days ago
2006
3D-structures of proteins and potential ligands are the cornerstones of rational drug design. The first brick to build upon is selecting a protein target and finding out whether b...
BMCBI
2006
14 years 18 days ago
2006
Background: The increasing number of known protein structures provides valuable information about pharmaceutical targets. Drug binding sites are identifiable and suitable lead com...
BMCBI
2006
14 years 18 days ago
2006
Background: Prediction of human cell response to anti-cancer drugs (compounds) from microarray data is a challenging problem, due to the noise properties of microarrays as well as...
CCE
2008
14 years 20 days ago
2008
Administration of certain drugs at a steady rate results in deterioration of drug effect, also known as drug tolerance. Periodic delivery is an attractive option for minimizing to...
BMCBI
2008
14 years 20 days ago
2008
Background: A priori analysis of the activity of drugs on the target protein by computational approaches can be useful in narrowing down drug candidates for further experimental t...